| 2020-08-29 21:00:34August 29, 2020 | Austin Peay vs. Central Arkansas (FCS Kickoff Classic) | 17 - 24 | Cramton Bowl | Montgomery, AL |
| 2020-09-12 16:00:51September 12, 2020 | Austin Peay at Pitt | 0 - 55 | Heinz Field | Pirrsburgh, PA |
| 2020-09-12 19:00:07September 12, 2020 | Missouri State at Oklahoma | 0 - 48 | Memorial Stadium (Oklahoma) | Norman, OK |
| 2020-09-19 12:00:26September 19, 2020 | Austin Peay at Cincinnati | 20 - 55 | Nippert Stadium | Cincinnati, OH |
| 2020-09-26 20:00:45September 26, 2020 | Missouri State at Central Arkansas | 20 - 27 | Estes Stadium | Conway, AR |
| 2020-10-03 15:30:03October 3, 2020 | Central Arkansas at North Dakota State | 28 - 39 | Fargodome | Fargo, ND |
| 2020-10-03 16:00:45October 3, 2020 | Jacksonville State at Florida State | 24 - 41 | Doak Campbell Stadium | Tallahassee, FL |
| 2020-10-10 15:00:48October 10, 2020 | Mercer at Jacksonville State | 28 - 34 | JSU Stadium | Jacksonville, AL |
| 2020-10-17 14:00:24October 17, 2020 | Jacksonville State at North Alabama | 24 - 17 | Braly Stadium | Florence, AL |
| 2020-10-17 20:20:09October 17, 2020 | Central Arkansas at Missouri State | 33 - 24 | Plaster Stadium | Springfield, MO |
| 2020-10-23 19:00:15October 23, 2020 | Jacksonville State at Florida International | 19 - 10 | Riccardo Silva Stadium | Miami, FL |
| 2020-10-24 12:00:16October 24, 2020 | Mercer at Army West Point | 3 - 49 | Michie Stadium | West Point, NY |
| 2020-10-24 16:00:11October 24, 2020 | Chattanooga at Western Kentucky | 10 - 13 | Houchens-Smith Stadium | Bowling Green, KY |
| 2020-10-30 19:00:07October 30, 2020 | Southeast Missouri State at Southern Illinois (War for the Wheel) | 17 - 20 | Saluki Stadium | Carbondale, IL |
| 2020-10-31 15:00:06October 31, 2020 | Abilene Christian at Mercer | 20 - 17 | Five Star Stadium | Macon, GA |
| 2021-02-13 19:00:23February 13, 2021 | McNeese State at Tarleton State | 19:00:237:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-02-19 19:00:20February 19, 2021 | Western Illinois at South Dakota | 19:00:207:00 pm | DakotaDome | Vermillion, SD |
| 2021-02-19 20:00:22February 19, 2021 | Illinois State at Northern Iowa | 20:00:228:00 pm | UNI-Dome | Cedar Falls, IA |
| 2021-02-20 13:00:13February 20, 2021 | South Dakota State at Southern Illinois | 13:00:131:00 pm | Saluki Stadium | Carbondale, IL |
| 2021-02-20 13:00:23February 20, 2021 | Missouri State at North Dakota | 13:00:231:00 pm | Alerus Center | Grand Forks, ND |
| 2021-02-20 23:59:00February 20, 2021 | Northwestern State at Lamar | 23:59:00TBD | Provost Umphrey Stadium | Beaumont, TX |
| 2021-02-20 23:59:10February 20, 2021 | Samford at East Tennessee State | 23:59:10TBD | Greene Stadium | Johnson City, TN |
| 2021-02-20 23:59:29February 20, 2021 | Sam Houston State at Incarnate Word | 23:59:29TBD | Benson Stadium | San Antonio, TX |
| 2021-02-20 23:59:49February 20, 2021 | Tarleton State at New Mexico State | 23:59:49TBD | Aggie Memorial Stadium | Las Cruces, NM |
| 2021-02-20 23:59:49February 20, 2021 | Delaware State at Morgan State | 23:59:49TBD | Hughes Memorial Stadium | Baltimore, MD |
| 2021-02-20 23:59:49February 20, 2021 | Norfolk State at Howard | 23:59:49TBD | Greene Stadium | Washington, DC |
| 2021-02-20 23:59:49February 20, 2021 | North Carolina Central at South Carolina State | 23:59:49TBD | Oliver C. Dawson Stadium | Orangeburg, SC |
| 2021-02-21 14:00:15February 21, 2021 | Edward Waters at Jackson State | 14:00:152:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-02-21 14:00:28February 21, 2021 | Austin Peay at Tennessee Tech | 14:00:282:00 pm | Tucker Stadium | Cookeville, TN |
| 2021-02-21 14:00:40February 21, 2021 | Eastern Illinois at UT Martin | 14:00:402:00 pm | Graham Stadium | Martin, TN |
| 2021-02-21 15:00:12February 21, 2021 | Jacksonville State at Tennessee State | 15:00:123:00 pm | Hale Stadium | Nashville, TN |
| 2021-02-21 15:00:36February 21, 2021 | Murray State at Southeast Missouri State | 15:00:363:00 pm | Houck Field | Cape Girardeau, MO |
| 2021-02-21 15:30:46February 21, 2021 | Youngstown State at North Dakota State | 15:30:463:30 pm | Fargodome | Fargo, ND |
| 2021-02-26 19:00:57February 26, 2021 | Northern Iowa at South Dakota | 19:00:577:00 pm | DakotaDome | Vermillion, SD |
| 2021-02-26 23:59:25February 26, 2021 | Southern at Alabama State | 23:59:25TBD | ASU Stadium | Montgomery, AL |
| 2021-02-27 12:00:49February 27, 2021 | Robert Morris at James Madison | 12:00:4912:00 pm | Bridgeforth Stadium | Harrisonburg, VA |
| 2021-02-27 13:00:00February 27, 2021 | Indiana State at Southern Illinois | 13:00:00Canceled | Saluki Stadium | Carbondale, IL |
| 2021-02-27 13:00:04February 27, 2021 | South Dakota State at North Dakota | 13:00:041:00 pm | Alerus Center | Grand Forks, ND |
| 2021-02-27 13:00:29February 27, 2021 | Incarnate Word at McNeese State | 13:00:291:00 pm | Cowboy Stadium | Lake Charles, LA |
| 2021-02-27 13:00:49February 27, 2021 | Shorter at Kennesaw State | 13:00:491:00 pm | Fifth Third Bank Stadium | Kennesaw, GA |
| 2021-02-27 15:00:09February 27, 2021 | Illinois State at Missouri State | 15:00:093:00 pm | Plaster Stadium | Springfield, MO |
| 2021-02-27 15:00:49February 27, 2021 | Dixie State at Tarleton State | 15:00:493:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-02-27 16:00:47February 27, 2021 | Grambling State vs. Prairie View A&M (State Fair Classic) | 16:00:474:00 pm | Cotton Bowl | Dallas, TX |
| 2021-02-27 16:00:52February 27, 2021 | Southern Utah at Cal Poly | 16:00:524:00 pm | Alex G. Spanos Stadium | San Luis Obispo, CA |
| 2021-02-27 19:00:20February 27, 2021 | Southeastern Louisiana at Sam Houston State | 19:00:207:00 pm | Bowers Stadium | Huntsville, TX |
| 2021-02-27 19:00:46February 27, 2021 | Mississippi Valley State at Jackson State | 19:00:467:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-02-27 20:31:52February 27, 2021 | Eastern Washington at Portland State | 20:31:52Canceled | Hillsboro Stadium | Hillsboro, OR |
| 2021-02-27 21:26:10February 27, 2021 | Weber State at Idaho State | 21:26:10TBD | Holt Arena | Pocatello, ID |
| 2021-02-27 21:55:19February 27, 2021 | Northern Colorado at Idaho | 21:55:19TBD | Kibbie Dome | Moscow, ID |
| 2021-02-27 23:01:50February 27, 2021 | Montana at Northern Arizona | 23:01:50Canceled | Walkup Skydome | Flagstaff, AZ |
| 2021-02-27 23:59:04February 27, 2021 | Alcorn State at Alabama A&M | 23:59:04TBD | Louis Crews Stadium | Huntsville, AL |
| 2021-02-27 23:59:34February 27, 2021 | Texas Southern at Arkansas-Pine Bluff | 23:59:34TBD | Simmons Bank Field | Pine Bluff, AR |
| 2021-02-27 23:59:49February 27, 2021 | South Carolina State at North Carolina A+T | 23:59:49TBD | Truist Stadium | Greensboro, NC |
| 2021-02-27 23:59:49February 27, 2021 | Elon at Gardner-Webb | 23:59:49TBD | Spangler Stadium | Boiling Springs, NC |
| 2021-02-27 23:59:54February 27, 2021 | Montana State at UC Davis | 23:59:54Canceled | UC Davis Health Stadium | Davis, CA |
| 2021-02-27 23:59:56February 27, 2021 | Lamar at Nicholls | 23:59:56TBD | Guidry Stadium | Thibodaux, LA |
| 2021-02-28 15:00:09February 28, 2021 | UT Martin at Murray State | 15:00:093:00 pm | Stewart Stadium | Murray, KY |
| 2021-02-28 15:00:17February 28, 2021 | Tennessee State at Austin Peay | 15:00:173:00 pm | Houck Field | Clarksville, TN |
| 2021-02-28 15:00:42February 28, 2021 | Southeast Missouri State at Eastern Illinois | 15:00:423:00 pm | O'Brien Field | Charleston, IL |
| 2021-02-28 16:00:24February 28, 2021 | Tennessee Tech at Jacksonville State | 16:00:244:00 pm | JSU Stadium | Jacksonville, AL |
| 2021-03-04 18:00:44March 4, 2021 | South Dakota at North Dakota | 18:00:446:00 pm | Alerus Center | Grand Forks, ND |
| 2021-03-06 01:42:41March 6, 2021 | Idaho at Idaho State | 01:42:41TBD | Holt Arena | Pocatello, ID |
| 2021-03-06 01:49:13March 6, 2021 | Montana State at Weber State | 01:49:13Canceled | Stewart Stadium | Ogden, UT |
| 2021-03-06 01:50:46March 6, 2021 | Portland State at Northern Arizona | 01:50:46Canceled | Walkup Skydome | Flagstaff, AZ |
| 2021-03-06 12:00:49March 6, 2021 | Maine at Delaware | 12:00:4912:00 pm | Delaware Stadium | Newark, DE |
| 2021-03-06 12:00:55March 6, 2021 | Villanova at Stony Brook | 12:00:5512:00 pm | LaValle Stadium | Stony Brook, NY |
| 2021-03-06 13:00:06March 6, 2021 | Jackson State at Grambling State | 13:00:061:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-06 13:00:08March 6, 2021 | William and Mary at Richmond | 13:00:081:00 pm | Robins Stadium | Richmond, VA |
| 2021-03-06 13:00:54March 6, 2021 | North Dakota State at Indiana State | 13:00:54Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-03-06 16:00:14March 6, 2021 | UC Davis at Cal Poly | 16:00:144:00 pm | Alex G. Spanos Stadium | San Luis Obispo, CA |
| 2021-03-06 16:26:48March 6, 2021 | Southern Utah at Northern Colorado | 16:26:48TBD | Nottingham Field | Greeley, CO |
| 2021-03-06 19:00:54March 6, 2021 | McNeese State at Southeastern Louisiana | 19:00:547:00 pm | Strawberry Stadium | Hammond, LA |
| 2021-03-06 20:00:07March 6, 2021 | Texas Southern at Prairie View A&M | 20:00:078:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-06 22:51:49March 6, 2021 | Montana at Eastern Washington | 22:51:49Canceled | Roos Field | Cheney, WA |
| 2021-03-06 23:59:09March 6, 2021 | Alabama A&M at Mississippi Valley State | 23:59:09TBD | Rice-Totten Stadium | Itta Bena, MS |
| 2021-03-06 23:59:11March 6, 2021 | Alabama State at Alcorn State | 23:59:11TBD | Spinks-Casem Stadium | Lorman, MS |
| 2021-03-06 23:59:14March 6, 2021 | Arkansas-Pine Bluff at Southern | 23:59:14TBD | A.W. Mumford Stadium | Baton Rouge, LA |
| 2021-03-06 23:59:22March 6, 2021 | Southern Illinois at Youngstown State | 23:59:22TBD | Stambaugh Stadium | Youngstown, OH |
| 2021-03-06 23:59:27March 6, 2021 | Samford at Furman | 23:59:27TBD | Paladin Stadium | Greenville, SC |
| 2021-03-06 23:59:40March 6, 2021 | Missouri State at Northern Iowa | 23:59:40TBD | UNI-Dome | Cedar Falls, IA |
| 2021-03-06 23:59:41March 6, 2021 | Western Illinois at Illinois State | 23:59:41TBD | Hancock Stadium | Normal, IL |
| 2021-03-06 23:59:45March 6, 2021 | Incarnate Word at Lamar | 23:59:45TBD | Provost Umphrey Stadium | Beaumont, TX |
| 2021-03-06 23:59:49March 6, 2021 | Dixie State at New Mexico State | 23:59:49TBD | Aggie Memorial Stadium | Las Cruces, NM |
| 2021-03-06 23:59:49March 6, 2021 | Howard at Delaware State | 23:59:49TBD | Alumni Stadium (Delaware State) | Dover, DE |
| 2021-03-06 23:59:49March 6, 2021 | Norfolk State at Morgan State | 23:59:49TBD | Hughes Memorial Stadium | Baltimore, MD |
| 2021-03-06 23:59:49March 6, 2021 | North Carolina Central at North Carolina A+T | 23:59:49TBD | Truist Stadium | Greensboro, NC |
| 2021-03-06 23:59:49March 6, 2021 | James Madison at Elon | 23:59:49TBD | Rhodes Stadium | Elon. NC |
| 2021-03-06 23:59:49March 6, 2021 | Albany at New Hampshire | 23:59:49TBD | Wildcat Stadium | Durham, NH |
| 2021-03-06 23:59:58March 6, 2021 | Nicholls at Northwestern State | 23:59:58TBD | Turpin Stadium | Natchitoches, LA |
| 2021-03-13 12:00:00March 13, 2021 | Stony Brook at Delaware | 12:00:0012:00 pm | Delaware Stadium | Newark, DE |
| 2021-03-13 12:00:26March 13, 2021 | Albany at Maine | 12:00:2612:00 pm | Alfond Stadium | Orono, ME |
| 2021-03-13 13:00:11March 13, 2021 | Lamar at McNeese State | 13:00:111:00 pm | Cowboy Stadium | Lake Charles, LA |
| 2021-03-13 13:00:20March 13, 2021 | Nicholls at Sam Houston State | 13:00:201:00 pm | Bowers Stadium | Huntsville, TX |
| 2021-03-13 13:00:35March 13, 2021 | South Dakota at Indiana State | 13:00:35Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-03-13 13:00:49March 13, 2021 | Charleston Southern at Kennesaw State | 13:00:491:00 pm | Fifth Third Bank Stadium | Kennesaw, GA |
| 2021-03-13 13:00:54March 13, 2021 | Cal Poly at Montana | 13:00:54Canceled | Washington-Grizzly Stadium | Missoula, MT |
| 2021-03-13 14:00:15March 13, 2021 | Idaho State at Southern Utah | 14:00:152:00 pm | Eccles Coliseum | Cedar City, UT |
| 2021-03-13 14:53:28March 13, 2021 | Eastern Washington at UC Davis | 14:53:28TBD | UC Davis Health Stadium | Davis, CA |
| 2021-03-13 14:54:14March 13, 2021 | Northern Arizona at Weber State | 14:54:14TBD | Stewart Stadium | Ogden, UT |
| 2021-03-13 15:30:04March 13, 2021 | Illinois State at North Dakota State | 15:30:043:30 pm | Fargodome | Fargo, ND |
| 2021-03-13 15:31:17March 13, 2021 | Northern Colorado at Montana State | 15:31:17Canceled | Bobcat Stadium | Bozeman, MT |
| 2021-03-13 16:00:18March 13, 2021 | Elon at Richmond | 16:00:184:00 pm | Robins Stadium | Richmond, VA |
| 2021-03-13 16:00:47March 13, 2021 | William and Mary at James Madison | 16:00:474:00 pm | Bridgeforth Stadium | Harrisonburg, VA |
| 2021-03-13 19:00:17March 13, 2021 | Northwestern State at Southeastern Louisiana | 19:00:177:00 pm | Strawberry Stadium | Hammond, LA |
| 2021-03-13 21:00:35March 13, 2021 | Tarleton State at Dixie State | 21:00:359:00 pm | Greater Zion Stadium | St. George, UT |
| 2021-03-13 21:55:19March 13, 2021 | Portland State at Idaho | 21:55:19Canceled | Kibbie Dome | Moscow, ID |
| 2021-03-13 22:51:49March 13, 2021 | Monmouth at Robert Morris | 22:51:49TBD | Joe Walton Stadium | Moon Township, PA |
| 2021-03-13 23:59:36March 13, 2021 | Furman at East Tennessee State | 23:59:36TBD | Greene Stadium | Johnson City, TN |
| 2021-03-13 23:59:41March 13, 2021 | Youngstown State at South Dakota State | 23:59:41TBD | Dykhouse Stadium | Brookings, SD |
| 2021-03-13 23:59:49March 13, 2021 | Rhode Island at Villanova | 23:59:49TBD | Villanova Stadium | Villanova, PA |
| 2021-03-13 23:59:53March 13, 2021 | Northern Iowa at Western Illinois | 23:59:53TBD | Hanson Field | Macomb, IL |
| 2021-03-14 14:00:43March 14, 2021 | Jacksonville State at UT Martin | 14:00:432:00 pm | Graham Stadium | Martin, TN |
| 2021-03-14 14:00:55March 14, 2021 | Eastern Illinois at Tennessee State | 14:00:552:00 pm | Hale Stadium | Nashville, TN |
| 2021-03-14 15:00:50March 14, 2021 | Southern Illinois at Missouri State | 15:00:503:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-14 15:00:59March 14, 2021 | Austin Peay at Southeast Missouri State | 15:00:593:00 pm | Houck Field | Cape Girardeau, MO |
| 2021-03-14 23:59:57March 14, 2021 | Murray State at Tennessee Tech | 23:59:57TBD | Tucker Stadium | Cookeville, TN |
| 2021-03-20 12:00:40March 20, 2021 | Maine at Stony Brook | 12:00:4012:00 pm | LaValle Stadium | Stony Brook, NY |
| 2021-03-20 12:00:43March 20, 2021 | Delaware at New Hampshire | 12:00:4312:00 pm | Wildcat Stadium | Durham, NH |
| 2021-03-20 13:00:02March 20, 2021 | Arkansas-Pine Bluff at Grambling State | 13:00:021:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-20 13:00:36March 20, 2021 | Alabama A&M at Prairie View A&M | 13:00:361:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-20 13:00:49March 20, 2021 | Dixie State at Kennesaw State | 13:00:491:00 pm | Fifth Third Bank Stadium | Kennesaw, GA |
| 2021-03-20 13:00:54March 20, 2021 | Northern Iowa at Southern Illinois | 13:00:541:00 pm | Saluki Stadium | Carbondale, IL |
| 2021-03-20 15:00:23March 20, 2021 | North Dakota State at South Dakota | 15:00:233:00 pm | DakotaDome | Vermillion, SD |
| 2021-03-20 16:00:04March 20, 2021 | Elon at William and Mary | 16:00:044:00 pm | Zable Stadium | Williamsburg, VA |
| 2021-03-20 16:00:06March 20, 2021 | Richmond at James Madison | 16:00:064:00 pm | Bridgeforth Stadium | Harrisonburg, VA |
| 2021-03-20 22:51:49March 20, 2021 | Monmouth at Gardner-Webb | 22:51:49TBD | Spangler Stadium | Boiling Springs, NC |
| 2021-03-20 22:51:49March 20, 2021 | Robert Morris at Charleston Southern | 22:51:49TBD | Buccaneer Field | Charleston, SC |
| 2021-03-20 23:59:04March 20, 2021 | Indiana State at Youngstown State | 23:59:04Canceled | Stambaugh Stadium | Youngstown, OH |
| 2021-03-20 23:59:06March 20, 2021 | Southeastern Louisiana at Incarnate Word | 23:59:06TBD | Benson Stadium | San Antonio, TX |
| 2021-03-20 23:59:07March 20, 2021 | McNeese State at Northwestern State | 23:59:07TBD | Turpin Stadium | Natchitoches, LA |
| 2021-03-20 23:59:08March 20, 2021 | Sam Houston State at Lamar | 23:59:08TBD | Provost Umphrey Stadium | Beaumont, TX |
| 2021-03-20 23:59:19March 20, 2021 | Jackson State at Alabama State | 23:59:19TBD | ASU Stadium | Montgomery, AL |
| 2021-03-20 23:59:28March 20, 2021 | Alcorn State at Mississippi Valley State | 23:59:28TBD | Rice-Totten Stadium | Itta Bena, MS |
| 2021-03-20 23:59:29March 20, 2021 | Western Illinois at South Dakota State | 23:59:29TBD | Dykhouse Stadium | Brookings, SD |
| 2021-03-20 23:59:35March 20, 2021 | Chattanooga at Furman | 23:59:35TBD | Paladin Stadium | Greenville, SC |
| 2021-03-20 23:59:49March 20, 2021 | Morgan State at Howard | 23:59:49TBD | Greene Stadium | Washington, DC |
| 2021-03-20 23:59:49March 20, 2021 | Delaware State at Norfolk State | 23:59:49TBD | Dick Price Stadium | Norfolk, VA |
| 2021-03-20 23:59:49March 20, 2021 | South Carolina State at North Carolina Central | 23:59:49TBD | O'Kelly-Riddick Stadium | Durham, NC |
| 2021-03-20 23:59:49March 20, 2021 | Rhode Island at Albany | 23:59:49TBD | Bob Ford Field | Albany, NY |
| 2021-03-20 23:59:51March 20, 2021 | North Dakota at Illinois State | 23:59:51TBD | Hancock Stadium | Normal, IL |
| 2021-03-20 23:59:53March 20, 2021 | Southern at Texas Southern | 23:59:53TBD | | Houston, TX |
| 2021-03-21 14:00:39March 21, 2021 | Tennessee Tech at Eastern Illinois | 14:00:392:00 pm | O'Brien Field | Charleston, IL |
| 2021-03-21 15:00:04March 21, 2021 | UT Martin at Austin Peay | 15:00:043:00 pm | Fortera Stadium | Clarksville, TN |
| 2021-03-21 15:00:23March 21, 2021 | Southeast Missouri State at Jacksonville State | 15:00:233:00 pm | JSU Stadium | Jacksonville, AL |
| 2021-03-21 15:00:34March 21, 2021 | Tennessee State at Murray State | 15:00:343:00 pm | Roy Stewart Stadium | Murray, KY |
| 2021-03-27 12:00:58March 27, 2021 | Mercer at Chattanooga | 12:00:5812:00 pm | Finley Stadium | Chattanooga, TN |
| 2021-03-27 13:00:15March 27, 2021 | James Madison at William and Mary | 13:00:151:00 pm | Zable Stadium | Williamsburg, VA |
| 2021-03-27 13:00:54March 27, 2021 | Montana State at Montana | 13:00:54Canceled | Washington-Grizzly Stadium | Missoula, MT |
| 2021-03-27 14:00:26March 27, 2021 | Weber State at Southern Utah | 14:00:262:00 pm | Eccles Coliseum | Cedar City, UT |
| 2021-03-27 14:53:28March 27, 2021 | UC Davis at Portland State | 14:53:28Canceled | Hillsboro Stadium | Hillsboro, OR |
| 2021-03-27 15:00:37March 27, 2021 | North Dakota State at Missouri State | 15:00:373:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-27 16:00:14March 27, 2021 | Northern Arizona at Cal Poly | 16:00:144:00 pm | Alex G. Spanos Stadium | San Luis Obispo, CA |
| 2021-03-27 16:26:48March 27, 2021 | Idaho State at Northern Colorado | 16:26:48TBD | Nottingham Field | Greeley, CO |
| 2021-03-27 19:00:18March 27, 2021 | Prairie View A&M at Jackson State | 19:00:187:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-03-27 21:55:19March 27, 2021 | Eastern Washington at Idaho | 21:55:19TBD | Kibbie Dome | Moscow, ID |
| 2021-03-27 22:51:49March 27, 2021 | Kennesaw State at Gardner-Webb | 22:51:49TBD | Spangler Stadium | Boiling Springs, NC |
| 2021-03-27 23:59:00March 27, 2021 | Indiana State at South Dakota State | 23:59:00Canceled | Dykhouse Stadium | Brookings, SD |
| 2021-03-27 23:59:04March 27, 2021 | Alabama State at Arkansas-Pine Bluff | 23:59:04TBD | Simmons Bank Field | Pine Bluff, AR |
| 2021-03-27 23:59:09March 27, 2021 | Grambling State at Alabama A&M | 23:59:09TBD | Louis Crews Stadium | Huntsville, AL |
| 2021-03-27 23:59:21March 27, 2021 | Incarnate Word at Nicholls | 23:59:21TBD | Guidry Stadium | Thibodaux, LA |
| 2021-03-27 23:59:31March 27, 2021 | North Dakota at Western Illinois | 23:59:31TBD | Hanson Field | Macomb, IL |
| 2021-03-27 23:59:32March 27, 2021 | Alcorn State at Southern | 23:59:32TBD | A.W. Mumford Stadium | Baton Rouge, LA |
| 2021-03-27 23:59:34March 27, 2021 | South Dakota at Illinois State | 23:59:34TBD | Hancock Stadium | Normal, IL |
| 2021-03-27 23:59:49March 27, 2021 | Charleston Southern at Monmouth | 23:59:49TBD | Kessler Stadium | West Long Branch, NJ |
| 2021-03-27 23:59:49March 27, 2021 | North Carolina A+T at South Carolina State | 23:59:49TBD | Oliver C. Dawson Stadium | Orangeburg, SC |
| 2021-03-27 23:59:49March 27, 2021 | Delaware at Rhode Island | 23:59:49TBD | Meade Stadium | Kingston, RI |
| 2021-03-27 23:59:49March 27, 2021 | Richmond at Elon | 23:59:49TBD | Rhodes Stadium | Elon. NC |
| 2021-03-27 23:59:49March 27, 2021 | Stony Brook at Albany | 23:59:49TBD | Bob Ford Field | Albany, NY |
| 2021-03-27 23:59:49March 27, 2021 | New Hampshire at Villanova | 23:59:49TBD | Villanova Stadium | Villanova, PA |
| 2021-03-27 23:59:59March 27, 2021 | Northern Iowa at Youngstown State | 23:59:59TBD | Stambaugh Stadium | Youngstown, OH |
| 2021-03-28 15:00:53March 28, 2021 | UT Martin at Tennessee State | 15:00:533:00 pm | Hale Stadium | Nashville, TN |
| 2021-03-28 15:00:56March 28, 2021 | Eastern Illinois at Murray State | 15:00:563:00 pm | Roy Stewart Stadium | Murray, KY |
| 2021-03-28 15:00:57March 28, 2021 | Austin Peay at Jacksonville State | 15:00:573:00 pm | JSU Stadium | Jacksonville, AL |
| 2021-03-28 15:00:57March 28, 2021 | Tennessee Tech at Southeast Missouri State | 15:00:573:00 pm | Houck Field | Cape Girardeau, MO |
| 2021-04-01 23:59:35April 1, 2021 | Sam Houston State at Northwestern State | 23:59:35TBD | Turpin Stadium | Natchitoches, LA |
| 2021-04-03 01:50:46April 3, 2021 | Southern Utah at Northern Arizona | 01:50:46TBD | Walkup Skydome | Flagstaff, AZ |
| 2021-04-03 12:00:37April 3, 2021 | Villanova at Maine | 12:00:3712:00 pm | Alfond Stadium | Orono, ME |
| 2021-04-03 12:00:42April 3, 2021 | Southern Illinois at North Dakota | 12:00:4212:00 pm | Alerus Center | Grand Forks, ND |
| 2021-04-03 12:00:43April 3, 2021 | James Madison at Richmond | 12:00:4312:00 pm | Robins Stadium | Richmond, VA |
| 2021-04-03 12:00:50April 3, 2021 | Albany at Delaware | 12:00:5012:00 pm | Delaware Stadium | Newark, DE |
| 2021-04-03 13:00:30April 3, 2021 | Illinois State at Indiana State | 13:00:30Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-04-03 13:00:49April 3, 2021 | Robert Morris at Kennesaw State | 13:00:491:00 pm | Fifth Third Bank Stadium | Kennesaw, GA |
| 2021-04-03 14:00:03April 3, 2021 | Southeast Missouri State at UT Martin | 14:00:032:00 pm | Graham Stadium | Martin, TN |
| 2021-04-03 14:00:09April 3, 2021 | Jacksonville State at Eastern Illinois | 14:00:092:00 pm | O'Brien Field | Charleston, IL |
| 2021-04-03 14:00:25April 3, 2021 | Nicholls at McNeese State | 14:00:252:00 pm | Cowboy Stadium | Lake Charles, LA |
| 2021-04-03 14:53:28April 3, 2021 | UC Davis at Idaho State | 14:53:28TBD | Holt Arena | Pocatello, ID |
| 2021-04-03 14:54:14April 3, 2021 | Northern Colorado at Weber State | 14:54:14TBD | Stewart Stadium | Ogden, UT |
| 2021-04-03 15:30:01April 3, 2021 | South Dakota State at North Dakota State (Dakota Marker) | 15:30:013:30 pm | Fargodome | Fargo, ND |
| 2021-04-03 15:30:03April 3, 2021 | Missouri State at South Dakota | 15:30:033:30 pm | DakotaDome | Vermillion, SD |
| 2021-04-03 15:31:17April 3, 2021 | Eastern Washington at Montana State | 15:31:17Canceled | Bobcat Stadium | Bozeman, MT |
| 2021-04-03 19:00:03April 3, 2021 | Lamar at Southeastern Louisiana | 19:00:037:00 pm | Strawberry Stadium | Hammond, LA |
| 2021-04-03 19:00:19April 3, 2021 | Southern at Jackson State | 19:00:197:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-04-03 20:31:52April 3, 2021 | Cal Poly at Portland State | 20:31:52Canceled | Hillsboro Stadium | Hillsboro, OR |
| 2021-04-03 21:55:19April 3, 2021 | Montana at Idaho | 21:55:19Canceled | Kibbie Dome | Moscow, ID |
| 2021-04-03 23:59:08April 3, 2021 | Grambling State at Texas Southern | 23:59:08TBD | | Houston, TX |
| 2021-04-03 23:59:17April 3, 2021 | Youngstown State at Western Illinois | 23:59:17TBD | Hanson Field | Macomb, IL |
| 2021-04-03 23:59:29April 3, 2021 | Furman at Mercer | 23:59:29TBD | Five Star Stadium | Macon, GA |
| 2021-04-03 23:59:30April 3, 2021 | Tennessee State at Tennessee Tech | 23:59:30TBD | Tucker Stadium | Cookeville, TN |
| 2021-04-03 23:59:49April 3, 2021 | William and Mary at Elon | 23:59:49TBD | Rhodes Stadium | Elon. NC |
| 2021-04-03 23:59:49April 3, 2021 | Morgan State at Delaware State | 23:59:49TBD | Alumni Stadium (Delaware State) | Dover, DE |
| 2021-04-03 23:59:49April 3, 2021 | Howard at Norfolk State | 23:59:49TBD | Dick Price Stadium | Norfolk, VA |
| 2021-04-03 23:59:49April 3, 2021 | North Carolina A+T at North Carolina Central | 23:59:49TBD | O'Kelly-Riddick Stadium | Durham, NC |
| 2021-04-03 23:59:49April 3, 2021 | Gardner-Webb at Charleston Southern | 23:59:49TBD | Buccaneer Field | Charleston, SC |
| 2021-04-03 23:59:49April 3, 2021 | New Hampshire at Rhode Island | 23:59:49TBD | Meade Stadium | Kingston, RI |
| 2021-04-03 23:59:50April 3, 2021 | Arkansas-Pine Bluff at Mississippi Valley State | 23:59:50TBD | Rice-Totten Stadium | Itta Bena, MS |
| 2021-04-03 23:59:57April 3, 2021 | Murray State at Austin Peay | 23:59:57TBD | Fortera Stadium | Clarksville, TN |
| 2021-04-10 01:23:17April 10, 2021 | East Tennessee State at Mercer | 01:23:17TBD | Five Star Stadium | Macon, GA |
| 2021-04-10 12:00:56April 10, 2021 | Stony Brook at New Hampshire | 12:00:5612:00 pm | Wildcat Stadium | - |
| 2021-04-10 13:00:17April 10, 2021 | Western Illinois at Southern Illinois | 13:00:171:00 pm | Saluki Stadium | Carbondale, IL |
| 2021-04-10 13:00:21April 10, 2021 | Richmond at William and Mary | 13:00:211:00 pm | Zable Stadium | Williamsburg, VA |
| 2021-04-10 13:00:40April 10, 2021 | Missouri State at Indiana State | 13:00:40Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-04-10 13:00:54April 10, 2021 | Portland State at Montana | 13:00:54Canceled | Washington-Grizzly Stadium | Missoula, MT |
| 2021-04-10 14:00:02April 10, 2021 | Samford at Chattanooga | 14:00:022:00 pm | Finley Stadium | Chattanooga, TN |
| 2021-04-10 14:53:28April 10, 2021 | Weber State at UC Davis | 14:53:28TBD | UC Davis Health Stadium | Davis, CA |
| 2021-04-10 15:00:35April 10, 2021 | Alabama A&M at Jackson State | 15:00:353:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-04-10 15:31:17April 10, 2021 | Idaho State at Montana State | 15:31:17Canceled | Bobcat Stadium | Bozeman, MT |
| 2021-04-10 16:00:49April 10, 2021 | Elon at James Madison | 16:00:494:00 pm | Bridgeforth Stadium | Harrisonburg, VA |
| 2021-04-10 16:26:48April 10, 2021 | Northern Arizona at Northern Colorado | 16:26:48TBD | Nottingham Field | Greeley, CO |
| 2021-04-10 17:00:40April 10, 2021 | Idaho at Southern Utah | 17:00:405:00 pm | Eccles Coliseum | Cedar City, UT |
| 2021-04-10 17:00:48April 10, 2021 | McNeese State at Sam Houston State | 17:00:485:00 pm | Bowers Stadium | Huntsville, TX |
| 2021-04-10 20:00:15April 10, 2021 | Southern at Prairie View A&M | 20:00:158:00 pm | Panther Stadium | Prairie View, TX |
| 2021-04-10 22:51:49April 10, 2021 | Cal Poly at Eastern Washington | 22:51:49TBD | Roos Field | Cheney, WA |
| 2021-04-10 23:59:06April 10, 2021 | Texas Southern at Alcorn State | 23:59:06TBD | Spinks-Casem Stadium | Lorman, MS |
| 2021-04-10 23:59:11April 10, 2021 | North Dakota at Youngstown State | 23:59:11TBD | Stambaugh Stadium | Youngstown, OH |
| 2021-04-10 23:59:15April 10, 2021 | South Dakota at South Dakota State | 23:59:15TBD | Dykhouse Stadium | Brookings, SD |
| 2021-04-10 23:59:36April 10, 2021 | Northwestern State at Incarnate Word | 23:59:36TBD | Benson Stadium | San Antonio, TX |
| 2021-04-10 23:59:44April 10, 2021 | Southeastern Louisiana at Nicholls | 23:59:44TBD | Guidry Stadium | Thibodaux, LA |
| 2021-04-10 23:59:45April 10, 2021 | Mississippi Valley State at Alabama State | 23:59:45TBD | ASU Stadium | Montgomery, AL |
| 2021-04-10 23:59:49April 10, 2021 | Delaware at Delaware State | 23:59:49TBD | Alumni Stadium (Delaware State) | Dover, DE |
| 2021-04-10 23:59:49April 10, 2021 | Kennesaw State at Monmouth | 23:59:49TBD | Kessler Stadium | West Long Branch, NJ |
| 2021-04-10 23:59:49April 10, 2021 | Gardner-Webb at Robert Morris | 23:59:49TBD | Joe Walton Stadium | Moon Township, PA |
| 2021-04-10 23:59:49April 10, 2021 | Maine at Rhode Island | 23:59:49TBD | Meade Stadium | Kingston, RI |
| 2021-04-10 23:59:49April 10, 2021 | Villanova at Albany | 23:59:49TBD | Bob Ford Field | Albany, NY |
| 2021-04-10 23:59:57April 10, 2021 | North Dakota State at Northern Iowa | 23:59:57TBD | UNI-Dome | Cedar Falls, IA |
| 2021-04-11 14:00:48April 11, 2021 | Austin Peay at Eastern Illinois | 14:00:482:00 pm | O'Brien Field | Charleston, IL |
| 2021-04-11 15:00:17April 11, 2021 | Jacksonville State at Murray State | 15:00:173:00 pm | Roy Stewart Stadium | Clarksville, TN |
| 2021-04-11 16:00:42April 11, 2021 | Tennessee Tech at UT Martin | 16:00:424:00 pm | Tucker Stadium | Martin, TN |
| 2021-04-11 23:59:15April 11, 2021 | Southeast Missouri State at Tennessee State | 23:59:15TBD | Hale Stadium | Nashville, TN |
| 2021-04-17 12:00:25April 17, 2021 | Rhode Island at Stony Brook | 12:00:2512:00 pm | LaValle Stadium | Stony Brook, NY |
| 2021-04-17 14:00:27April 17, 2021 | New Hampshire at Maine | 14:00:272:00 pm | Alfond Stadium | Orono, ME |
| 2021-04-17 15:00:40April 17, 2021 | Youngstown State at Missouri State | 15:00:403:00 pm | Plaster Stadium | Springfield, MO |
| 2021-04-17 15:30:36April 17, 2021 | North Dakota at North Dakota State | 15:30:363:30 pm | Fargodome | Fargo, ND |
| 2021-04-17 23:59:06April 17, 2021 | Southern Illinois at Illinois State | 23:59:06TBD | Hancock Stadium | Normal, IL |
| 2021-04-17 23:59:07April 17, 2021 | Grambling State vs. Southern (Bayou Classic) | 23:59:07TBD | Independence Stadium | Shreveport, LA |
| 2021-04-17 23:59:07April 17, 2021 | Mississippi Valley State at Texas Southern | 23:59:07TBD | | Houston, TX |
| 2021-04-17 23:59:12April 17, 2021 | Prairie View A&M at Arkansas-Pine Bluff | 23:59:12TBD | Simmons Bank Field | Pine Bluff, AR |
| 2021-04-17 23:59:35April 17, 2021 | Chattanooga at East Tennessee State | 23:59:35TBD | Greene Stadium | Johnson City, TN |
| 2021-04-17 23:59:38April 17, 2021 | Alabama AM vs. Alabama State (Magic City Classic) | 23:59:38TBD | Legion Field | Birmingham, AL |
| 2021-04-17 23:59:45April 17, 2021 | Indiana State at Western Illinois | 23:59:45Canceled | Hanson Field | Macomb, IL |
| 2021-04-17 23:59:49April 17, 2021 | MEAC Championship Game | 23:59:49TBD | | TBD |
| 2021-04-17 23:59:49April 17, 2021 | Delaware at Villanova | 23:59:49TBD | Villanova Stadium | Villanova, PA |
| 2021-04-17 23:59:52April 17, 2021 | Mercer at Samford | 23:59:52TBD | Seibert Stadium | Homefield, AL |
| 2021-04-17 23:59:54April 17, 2021 | South Dakota State at Northern Iowa | 23:59:54TBD | UNI-Dome | Cedar Falls, IA |
| 2021-04-17 23:59:58April 17, 2021 | Jackson State at Alcorn State | 23:59:58TBD | Spinks-Casem Stadium | Lorman, MS |
| 2021-05-01 23:59:49May 1, 2021 | SWAC Championship Game | 23:59:49TBD | | TBD |
