| 2021-02-21 14:00:15February 21, 2021 |   Jackson State 53, Edward Waters 0 | 14:00:152:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-02-26 19:00:25February 26, 2021 |   Southern at Alabama State | 19:00:257:00 pm | ASU Stadium | Montgomery, AL |
| 2021-03-06 13:00:06March 6, 2021 |  Jackson State at Grambling State | 13:00:061:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-06 19:00:09March 6, 2021 |   Alabama A&M at Mississippi Valley State | 19:00:097:00 pm | Rice-Totten Stadium | Itta Bena, MS |
| 2021-03-06 20:00:07March 6, 2021 |   Texas Southern at Prairie View A&M | 20:00:078:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-06 23:59:14March 6, 2021 |  Arkansas-Pine Bluff at Southern | 23:59:14TBD | A.W. Mumford Stadium | Baton Rouge, LA |
| 2021-03-13 23:59:47March 13, 2021 | Grambling State vs. Prairie View A&M (State Fair Classic) | 23:59:47TBD | Cotton Bowl | Dallas, TX |
| 2021-03-14 23:59:46March 14, 2021 | Mississippi Valley State at Jackson State | 23:59:46TBD | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-03-20 13:00:02March 20, 2021 | Arkansas-Pine Bluff at Grambling State | 13:00:021:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-20 13:00:36March 20, 2021 | Alabama A&M at Prairie View A&M | 13:00:361:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-20 23:59:19March 20, 2021 | Jackson State at Alabama State | 23:59:19TBD | ASU Stadium | Montgomery, AL |
| 2021-03-20 23:59:53March 20, 2021 | Southern at Texas Southern | 23:59:53TBD | | Houston, TX |
| 2021-03-27 19:00:04March 27, 2021 | Alabama State at Arkansas-Pine Bluff | 19:00:047:00 pm | Simmons Bank Field | Pine Bluff, AR |
| 2021-03-27 19:00:18March 27, 2021 | Prairie View A&M at Jackson State | 19:00:187:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-03-27 23:59:09March 27, 2021 | Grambling State at Alabama A&M | 23:59:09TBD | Louis Crews Stadium | Huntsville, AL |
| 2021-04-03 16:00:50April 3, 2021 | Arkansas-Pine Bluff at Mississippi Valley State | 16:00:504:00 pm | Rice-Totten Stadium | Itta Bena, MS |
| 2021-04-03 19:00:19April 3, 2021 | Southern at Jackson State | 19:00:197:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-04-03 23:59:08April 3, 2021 | Grambling State at Texas Southern | 23:59:08TBD | | Houston, TX |
| 2021-04-10 15:00:35April 10, 2021 | Alabama A&M at Jackson State | 15:00:353:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-04-10 20:00:15April 10, 2021 | Southern at Prairie View A&M | 20:00:158:00 pm | Panther Stadium | Prairie View, TX |
| 2021-04-10 23:59:45April 10, 2021 | Mississippi Valley State at Alabama State | 23:59:45TBD | ASU Stadium | Montgomery, AL |
| 2021-04-17 14:30:07April 17, 2021 | Grambling State vs. Southern (Bayou Classic) | 14:30:072:30 pm | Independence Stadium | Shreveport, LA |
| 2021-04-17 19:00:12April 17, 2021 | Prairie View A&M at Arkansas-Pine Bluff | 19:00:127:00 pm | Simmons Bank Field | Pine Bluff, AR |
| 2021-04-17 23:59:07April 17, 2021 | Mississippi Valley State at Texas Southern | 23:59:07TBD | | Houston, TX |
| 2021-04-17 23:59:38April 17, 2021 | Alabama AM vs. Alabama State (Magic City Classic) | 23:59:38TBD | Legion Field | Birmingham, AL |
| 2021-04-24 23:59:34April 24, 2021 | Texas Southern at Arkansas-Pine Bluff | 23:59:34TBD | Simmons Bank Field | Pine Bluff, AR |
