| 2021-02-21 14:00:15February 21, 2021 |   Jackson State 53, Edward Waters 0 | 14:00:152:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-02-26 19:00:25February 26, 2021 |   Southern 24, Alabama State 21 | 19:00:257:00 pm | ASU Stadium | Montgomery, AL |
| 2021-03-06 13:00:06March 6, 2021 |  Jackson State 33, Grambling State 28 | 13:00:061:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-06 13:30:50March 6, 2021 |   Alabama A&M 31, South Carolina State 7 | 13:30:501:30 pm | Oliver C. Dawson Stadium | Orangeburg, SC |
| 2021-03-06 14:30:14March 6, 2021 |  Arkansas-Pine Bluff 33, Southern 30 | 14:30:142:30 pm | A.W. Mumford Stadium | Baton Rouge, LA |
| 2021-03-06 20:00:07March 6, 2021 |   Prairie View A&M 20, Texas Southern 19 (Labor Day Classic) | 20:00:078:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-13 16:00:47March 13, 2021 | Prairie View A&M 17, Grambling State 10 (State Fair Classic) | 16:00:474:00 pm | Globe Life Park | Arlington, TX |
| 2021-03-14 14:00:46March 14, 2021 |  Jackson State 43, Mississippi Valley State 7 | 14:00:462:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-03-20 13:00:02March 20, 2021 | Arkansas-Pine Bluff 48, Grambling State 21 | 13:00:021:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-20 16:00:19March 20, 2021 | Alabama State 35, Jackson State 28 | 16:00:194:00 pm | ASU Stadium | Montgomery, AL |
| 2021-03-20 20:30:53March 20, 2021 | Southern 51, Texas Southern 23 | 20:30:538:30 pm | BBVA Stadium | Houston, TX |
| 2021-04-03 14:00:17April 3, 2021 | South Carolina State at Alabama State | 14:00:172:00 pm | Cramton Bowl | Montgomery, AL |
| 2021-04-03 16:00:50April 3, 2021 | Arkansas-Pine Bluff 24, Mississippi Valley State 17 | 16:00:504:00 pm | Rice-Totten Stadium | Itta Bena, MS |
| 2021-04-03 19:00:19April 3, 2021 | Southern 34, Jackson State 14 | 19:00:197:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-04-10 15:00:35April 10, 2021 | Alabama A&M 52, Jackson State 43 | 15:00:353:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
| 2021-04-10 15:00:45April 10, 2021 | Alabama State 42, Mississippi Valley State 17 | 15:00:453:00 pm | ASU Stadium | Montgomery, AL |
| 2021-04-17 14:30:07April 17, 2021 | Southern 49, Grambling State 7 (Bayou Classic) | 14:30:072:30 pm | Independence Stadium | Shreveport, LA |
| 2021-04-17 19:00:12April 17, 2021 | Arkansas-Pine Bluff 36, Prairie View A&M 31 | 19:00:127:00 pm | Simmons Bank Field | Pine Bluff, AR |
| 2021-04-17 19:30:38April 17, 2021 | Alabama A&M 38, Alabama State 14 (Magic City Classic) | 19:30:387:30 pm | Legion Field | Birmingham, AL |
| 2021-05-01 15:00:49May 1, 2021 | Alabama A&M 40, Arkansas-Pine Bluff, 33 (SWAC Championship Game) | 15:00:493:00 pm | Mississippi Veterans Memorial Stadium | Jackson, MS |
