| 2020-09-12 19:00:07September 12, 2020 | Missouri State at Oklahoma | 0 - 48 | Memorial Stadium (Oklahoma) | Norman, OK |
| 2020-09-26 20:00:45September 26, 2020 | Missouri State at Central Arkansas | 20 - 27 | Estes Stadium | Conway, AR |
| 2020-10-03 15:30:03October 3, 2020 | Central Arkansas at North Dakota State | 28 - 39 | Fargodome | Fargo, ND |
| 2020-10-17 20:20:09October 17, 2020 | Central Arkansas at Missouri State | 33 - 24 | Plaster Stadium | Springfield, MO |
| 2020-10-30 19:00:07October 30, 2020 | Southeast Missouri State at Southern Illinois (War for the Wheel) | 17 - 20 | Saluki Stadium | Carbondale, IL |
| 2021-02-19 19:00:20February 19, 2021 | Western Illinois at South Dakota | 19:00:207:00 pm | DakotaDome | Vermillion, SD |
| 2021-02-19 20:00:22February 19, 2021 | Illinois State at Northern Iowa | 20:00:228:00 pm | UNI-Dome | Cedar Falls, IA |
| 2021-02-20 13:00:13February 20, 2021 | South Dakota State at Southern Illinois | 13:00:131:00 pm | Saluki Stadium | Carbondale, IL |
| 2021-02-20 13:00:23February 20, 2021 | Missouri State at North Dakota | 13:00:231:00 pm | Alerus Center | Grand Forks, ND |
| 2021-02-21 15:30:46February 21, 2021 | Youngstown State at North Dakota State | 15:30:463:30 pm | Fargodome | Fargo, ND |
| 2021-02-26 19:00:57February 26, 2021 | Northern Iowa at South Dakota | 19:00:577:00 pm | DakotaDome | Vermillion, SD |
| 2021-02-27 13:00:00February 27, 2021 | Indiana State at Southern Illinois | 13:00:00Canceled | Saluki Stadium | Carbondale, IL |
| 2021-02-27 13:00:04February 27, 2021 | South Dakota State at North Dakota | 13:00:041:00 pm | Alerus Center | Grand Forks, ND |
| 2021-02-27 15:00:09February 27, 2021 | Illinois State at Missouri State | 15:00:093:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-04 18:00:44March 4, 2021 | South Dakota at North Dakota | 18:00:446:00 pm | Alerus Center | Grand Forks, ND |
| 2021-03-06 13:00:54March 6, 2021 | North Dakota State at Indiana State | 13:00:54Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-03-06 23:59:22March 6, 2021 | Southern Illinois at Youngstown State | 23:59:22TBD | Stambaugh Stadium | Youngstown, OH |
| 2021-03-06 23:59:40March 6, 2021 | Missouri State at Northern Iowa | 23:59:40TBD | UNI-Dome | Cedar Falls, IA |
| 2021-03-06 23:59:41March 6, 2021 | Western Illinois at Illinois State | 23:59:41TBD | Hancock Stadium | Normal, IL |
| 2021-03-13 13:00:35March 13, 2021 | South Dakota at Indiana State | 13:00:35Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-03-13 15:30:04March 13, 2021 | Illinois State at North Dakota State | 15:30:043:30 pm | Fargodome | Fargo, ND |
| 2021-03-13 23:59:41March 13, 2021 | Youngstown State at South Dakota State | 23:59:41TBD | Dykhouse Stadium | Brookings, SD |
| 2021-03-13 23:59:53March 13, 2021 | Northern Iowa at Western Illinois | 23:59:53TBD | Hanson Field | Macomb, IL |
| 2021-03-14 15:00:50March 14, 2021 | Southern Illinois at Missouri State | 15:00:503:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-20 13:00:54March 20, 2021 | Northern Iowa at Southern Illinois | 13:00:541:00 pm | Saluki Stadium | Carbondale, IL |
| 2021-03-20 15:00:23March 20, 2021 | North Dakota State at South Dakota | 15:00:233:00 pm | DakotaDome | Vermillion, SD |
| 2021-03-20 23:59:04March 20, 2021 | Indiana State at Youngstown State | 23:59:04Canceled | Stambaugh Stadium | Youngstown, OH |
| 2021-03-20 23:59:29March 20, 2021 | Western Illinois at South Dakota State | 23:59:29TBD | Dykhouse Stadium | Brookings, SD |
| 2021-03-20 23:59:51March 20, 2021 | North Dakota at Illinois State | 23:59:51TBD | Hancock Stadium | Normal, IL |
| 2021-03-27 15:00:37March 27, 2021 | North Dakota State at Missouri State | 15:00:373:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-27 23:59:00March 27, 2021 | Indiana State at South Dakota State | 23:59:00Canceled | Dykhouse Stadium | Brookings, SD |
| 2021-03-27 23:59:31March 27, 2021 | North Dakota at Western Illinois | 23:59:31TBD | Hanson Field | Macomb, IL |
| 2021-03-27 23:59:34March 27, 2021 | South Dakota at Illinois State | 23:59:34TBD | Hancock Stadium | Normal, IL |
| 2021-03-27 23:59:59March 27, 2021 | Northern Iowa at Youngstown State | 23:59:59TBD | Stambaugh Stadium | Youngstown, OH |
| 2021-04-03 12:00:42April 3, 2021 | Southern Illinois at North Dakota | 12:00:4212:00 pm | Alerus Center | Grand Forks, ND |
| 2021-04-03 13:00:30April 3, 2021 | Illinois State at Indiana State | 13:00:30Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-04-03 15:30:01April 3, 2021 | South Dakota State at North Dakota State (Dakota Marker) | 15:30:013:30 pm | Fargodome | Fargo, ND |
| 2021-04-03 15:30:03April 3, 2021 | Missouri State at South Dakota | 15:30:033:30 pm | DakotaDome | Vermillion, SD |
| 2021-04-03 23:59:17April 3, 2021 | Youngstown State at Western Illinois | 23:59:17TBD | Hanson Field | Macomb, IL |
| 2021-04-10 13:00:17April 10, 2021 | Western Illinois at Southern Illinois | 13:00:171:00 pm | Saluki Stadium | Carbondale, IL |
| 2021-04-10 13:00:40April 10, 2021 | Missouri State at Indiana State | 13:00:40Canceled | Memorial Stadium (Indiana State) | Terre Haute, IN |
| 2021-04-10 23:59:11April 10, 2021 | North Dakota at Youngstown State | 23:59:11TBD | Stambaugh Stadium | Youngstown, OH |
| 2021-04-10 23:59:15April 10, 2021 | South Dakota at South Dakota State | 23:59:15TBD | Dykhouse Stadium | Brookings, SD |
| 2021-04-10 23:59:57April 10, 2021 | North Dakota State at Northern Iowa | 23:59:57TBD | UNI-Dome | Cedar Falls, IA |
| 2021-04-17 15:00:40April 17, 2021 | Youngstown State at Missouri State | 15:00:403:00 pm | Plaster Stadium | Springfield, MO |
| 2021-04-17 15:30:36April 17, 2021 | North Dakota at North Dakota State | 15:30:363:30 pm | Fargodome | Fargo, ND |
| 2021-04-17 23:59:06April 17, 2021 | Southern Illinois at Illinois State | 23:59:06TBD | Hancock Stadium | Normal, IL |
| 2021-04-17 23:59:45April 17, 2021 | Indiana State at Western Illinois | 23:59:45Canceled | Hanson Field | Macomb, IL |
| 2021-04-17 23:59:54April 17, 2021 | South Dakota State at Northern Iowa | 23:59:54TBD | UNI-Dome | Cedar Falls, IA |
