| 2020-08-29 21:00:34August 29, 2020 | Austin Peay vs. Central Arkansas (FCS Kickoff Classic) | 17 - 24 | Cramton Bowl | Montgomery, AL |
| 2020-09-12 16:00:51September 12, 2020 | Austin Peay at Pitt | 0 - 55 | Heinz Field | Pirrsburgh, PA |
| 2020-09-19 12:00:26September 19, 2020 | Austin Peay at Cincinnati | 20 - 55 | Nippert Stadium | Cincinnati, OH |
| 2020-10-03 16:00:45October 3, 2020 | Jacksonville State at Florida State | 24 - 41 | Doak Campbell Stadium | Tallahassee, FL |
| 2020-10-10 15:00:48October 10, 2020 | Mercer at Jacksonville State | 28 - 34 | JSU Stadium | Jacksonville, AL |
| 2020-10-17 14:00:24October 17, 2020 | Jacksonville State at North Alabama | 24 - 17 | Braly Stadium | Florence, AL |
| 2020-10-23 19:00:15October 23, 2020 | Jacksonville State at Florida International | 19 - 10 | Riccardo Silva Stadium | Miami, FL |
| 2020-10-30 19:00:07October 30, 2020 | Southeast Missouri State at Southern Illinois (War for the Wheel) | 17 - 20 | Saluki Stadium | Carbondale, IL |
| 2021-02-21 14:00:28February 21, 2021 | Austin Peay at Tennessee Tech | 14:00:282:00 pm | Tucker Stadium | Cookeville, TN |
| 2021-02-21 14:00:40February 21, 2021 | Eastern Illinois at UT Martin | 14:00:402:00 pm | Graham Stadium | Martin, TN |
| 2021-02-21 15:00:12February 21, 2021 | Jacksonville State at Tennessee State | 15:00:123:00 pm | Hale Stadium | Nashville, TN |
| 2021-02-21 15:00:36February 21, 2021 | Murray State at Southeast Missouri State | 15:00:363:00 pm | Houck Field | Cape Girardeau, MO |
| 2021-02-28 15:00:09February 28, 2021 | UT Martin at Murray State | 15:00:093:00 pm | Stewart Stadium | Murray, KY |
| 2021-02-28 15:00:17February 28, 2021 | Tennessee State at Austin Peay | 15:00:173:00 pm | Houck Field | Clarksville, TN |
| 2021-02-28 15:00:42February 28, 2021 | Southeast Missouri State at Eastern Illinois | 15:00:423:00 pm | O'Brien Field | Charleston, IL |
| 2021-02-28 16:00:24February 28, 2021 | Tennessee Tech at Jacksonville State | 16:00:244:00 pm | JSU Stadium | Jacksonville, AL |
| 2021-03-14 14:00:43March 14, 2021 | Jacksonville State at UT Martin | 14:00:432:00 pm | Graham Stadium | Martin, TN |
| 2021-03-14 14:00:55March 14, 2021 | Eastern Illinois at Tennessee State | 14:00:552:00 pm | Hale Stadium | Nashville, TN |
| 2021-03-14 15:00:59March 14, 2021 | Austin Peay at Southeast Missouri State | 15:00:593:00 pm | Houck Field | Cape Girardeau, MO |
| 2021-03-14 23:59:57March 14, 2021 | Murray State at Tennessee Tech | 23:59:57TBD | Tucker Stadium | Cookeville, TN |
| 2021-03-21 14:00:39March 21, 2021 | Tennessee Tech at Eastern Illinois | 14:00:392:00 pm | O'Brien Field | Charleston, IL |
| 2021-03-21 15:00:04March 21, 2021 | UT Martin at Austin Peay | 15:00:043:00 pm | Fortera Stadium | Clarksville, TN |
| 2021-03-21 15:00:23March 21, 2021 | Southeast Missouri State at Jacksonville State | 15:00:233:00 pm | JSU Stadium | Jacksonville, AL |
| 2021-03-21 15:00:34March 21, 2021 | Tennessee State at Murray State | 15:00:343:00 pm | Roy Stewart Stadium | Murray, KY |
| 2021-03-28 15:00:53March 28, 2021 | UT Martin at Tennessee State | 15:00:533:00 pm | Hale Stadium | Nashville, TN |
| 2021-03-28 15:00:56March 28, 2021 | Eastern Illinois at Murray State | 15:00:563:00 pm | Roy Stewart Stadium | Murray, KY |
| 2021-03-28 15:00:57March 28, 2021 | Austin Peay at Jacksonville State | 15:00:573:00 pm | JSU Stadium | Jacksonville, AL |
| 2021-03-28 15:00:57March 28, 2021 | Tennessee Tech at Southeast Missouri State | 15:00:573:00 pm | Houck Field | Cape Girardeau, MO |
| 2021-04-03 14:00:03April 3, 2021 | Southeast Missouri State at UT Martin | 14:00:032:00 pm | Graham Stadium | Martin, TN |
| 2021-04-03 14:00:09April 3, 2021 | Jacksonville State at Eastern Illinois | 14:00:092:00 pm | O'Brien Field | Charleston, IL |
| 2021-04-03 23:59:30April 3, 2021 | Tennessee State at Tennessee Tech | 23:59:30TBD | Tucker Stadium | Cookeville, TN |
| 2021-04-03 23:59:57April 3, 2021 | Murray State at Austin Peay | 23:59:57TBD | Fortera Stadium | Clarksville, TN |
| 2021-04-11 14:00:48April 11, 2021 | Austin Peay at Eastern Illinois | 14:00:482:00 pm | O'Brien Field | Charleston, IL |
| 2021-04-11 15:00:17April 11, 2021 | Jacksonville State at Murray State | 15:00:173:00 pm | Roy Stewart Stadium | Clarksville, TN |
| 2021-04-11 16:00:42April 11, 2021 | Tennessee Tech at UT Martin | 16:00:424:00 pm | Tucker Stadium | Martin, TN |
| 2021-04-11 23:59:15April 11, 2021 | Southeast Missouri State at Tennessee State | 23:59:15TBD | Hale Stadium | Nashville, TN |
