| 2021-02-13 19:00:23February 13, 2021 |   McNeese State 40, Tarleton State 37 (2OT) | 19:00:237:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-02-21 17:00:49February 21, 2021 |  Tarleton State 43, New Mexico State 17 | 17:00:495:00 pm | Sun Bowl Stadium | El Paso, TX |
| 2021-02-27 12:00:49February 27, 2021 |   Delaware State 17, Howard 10 | 12:00:4912:00 pm | Alumni Stadium (Delaware State) | Dover, DE |
| 2021-02-27 15:00:49February 27, 2021 |  Dixie State 26, Tarleton State 14 | 15:00:493:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-03-06 13:30:50March 6, 2021 |   Alabama A&M 31, South Carolina State 7 | 13:30:501:30 pm | Oliver C. Dawson Stadium | Orangeburg, SC |
| 2021-03-06 15:00:55March 6, 2021 |  Tarleton State 39, Mississippi College 14 | 15:00:553:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-03-06 17:00:49March 6, 2021 | New Mexico State 36, Dixie State 29 | 17:00:495:00 pm | Sun Bowl Stadium | El Paso, TX |
| 2021-03-13 14:00:33March 13, 2021 | South Carolina State 17, Delaware State 9 | 14:00:332:00 pm | Oliver C. Dawson Stadium | Orangeburg, SC |
| 2021-03-13 21:00:35March 13, 2021 | Tarleton State 37, Dixie State 15 | 21:00:359:00 pm | Greater Zion Stadium | St. George, UT |
| 2021-03-20 13:00:49March 20, 2021 |  Kennesaw State 37, Dixie State 27 | 13:00:491:00 pm | Fifth Third Bank Stadium | Kennesaw, GA |
| 2021-03-20 19:00:26March 20, 2021 |  Tarleton State 33, Midwestern State 21 | 19:00:267:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-03-27 19:00:52March 27, 2021 |  Tarleton State 38, Northeastern State 0 | 19:00:527:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-03-27 21:00:39March 27, 2021 |  Dixie State 60, Fort Lewis 0 | 21:00:399:00 pm | Greater Zion Stadium | St. George, UT |
| 2021-04-01 19:00:42April 1, 2021 |  East Central 21, Tarleton State 14 | 19:00:427:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-04-03 13:00:49April 3, 2021 | Delaware State at Howard | 13:00:491:00 pm | Greene Stadium | Washington, DC |
| 2021-04-03 14:00:17April 3, 2021 |  South Carolina State at Alabama State | 14:00:172:00 pm | Cramton Bowl | Montgomery, AL |
| 2021-04-03 21:00:11April 3, 2021 |  New Mexico Highlands at Dixie State | 21:00:11Canceled | Greater Zion Stadium | St. George, UT |
| 2021-04-10 18:00:49April 10, 2021 |  Delaware 34, Delaware State 14 | 18:00:496:00 pm | Alumni Stadium (Delaware State) | Dover, DE |
| 2021-04-17 18:00:08April 17, 2021 | South Carolina State at Delaware State | 18:00:086:00 pm | Alumni Stadium (Delaware State) | Dover, DE |
Tarleton State
Dixie State
South Carolina State
Delaware State
Howard
