| 2021-03-06 12:00:22March 6, 2021 |   Southern Illinois 30, Youngstown State 22 | 12:00:2212:00 pm | Stambaugh Stadium | Youngstown, OH |
| 2021-03-06 12:00:49March 6, 2021 |   Delaware 37, Maine 0 | 12:00:4912:00 pm | Delaware Stadium | Newark, DE |
| 2021-03-06 12:00:55March 6, 2021 |   Villanova 16, Stony Brook 13 | 12:00:5512:00 pm | LaValle Stadium | Stony Brook, NY |
| 2021-03-06 13:00:00March 6, 2021 |   VMI 30, Western Carolina 7 | 13:00:001:00 pm | E.J. Whitmire Stadium | Cullowhee, NC |
| 2021-03-06 13:00:06March 6, 2021 |   Jackson State 33, Grambling State 28 | 13:00:061:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-06 13:00:07March 6, 2021 |   Chattanooga 25, The Citadel 24 (OT) | 13:00:071:00 pm | Johnson Hagood Stadium | Charleston, SC |
| 2021-03-06 13:00:08March 6, 2021 |   Richmond 21, William and Mary 14 | 13:00:081:00 pm | Robins Stadium | Richmond, VA |
| 2021-03-06 13:00:23March 6, 2021 |   Gardner-Webb 31, Presbyterian 24 (2OT) | 13:00:231:00 pm | Spangler Stadium | Boiling Springs, NC |
| 2021-03-06 13:00:27March 6, 2021 |   Furman 44, Samford 37 (OT) | 13:00:271:00 pm | Paladin Stadium | Greenville, SC |
| 2021-03-06 13:30:49March 6, 2021 |   James Madison 20, Elon 17 | 13:30:491:30 pm | Rhodes Stadium | Elon. NC |
| 2021-03-06 13:30:50March 6, 2021 |   Alabama A&M 31, South Carolina State 7 | 13:30:501:30 pm | Oliver C. Dawson Stadium | Orangeburg, SC |
| 2021-03-06 14:00:15March 6, 2021 |   Idaho State 26, Southern Utah 24 | 14:00:152:00 pm | Eccles Coliseum | Cedar City, UT |
| 2021-03-06 14:30:14March 6, 2021 |   Arkansas-Pine Bluff 33, Southern 30 | 14:30:142:30 pm | A.W. Mumford Stadium | Baton Rouge, LA |
| 2021-03-06 15:00:27March 6, 2021 |   UC Davis 27, Idaho 17 | 15:00:273:00 pm | Kibbie Dome | Moscow, ID |
| 2021-03-06 15:00:29March 6, 2021 |   South Dakota State 45, Western Illinois 10 | 15:00:293:00 pm | Dykhouse Stadium | Brookings, SD |
| 2021-03-06 15:00:37March 6, 2021 |   North Dakota State 25, Missouri State 0 | 15:00:373:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-06 15:00:55March 6, 2021 |   Tarleton State 39, Mississippi College 14 | 15:00:553:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-03-06 16:00:13March 6, 2021 |   Eastern Washington 45, Northern Arizona 13 | 16:00:134:00 pm | Roos Field | Cheney, WA |
| 2021-03-06 16:00:45March 6, 2021 |   Incarnate Word 42, Lamar 20 | 16:00:454:00 pm | Provost Umphrey Stadium | Beaumont, TX |
| 2021-03-06 17:00:22March 6, 2021 |   Northern Iowa 20, Illinois State 10 | 17:00:225:00 pm | UNI-Dome | Cedar Falls, IA |
| 2021-03-06 17:00:49March 6, 2021 |   New Mexico State 36, Dixie State 29 | 17:00:495:00 pm | Sun Bowl Stadium | El Paso, TX |
| 2021-03-06 19:00:54March 6, 2021 |   Southeastern Louisiana 25, McNeese 20 | 19:00:547:00 pm | Strawberry Stadium | Hammond, LA |
| 2021-03-06 19:00:58March 6, 2021 |   Nicholls 31, Northwestern State 24 | 19:00:587:00 pm | Turpin Stadium | Natchitoches, LA |
| 2021-03-06 20:00:07March 6, 2021 |   Prairie View A&M 20, Texas Southern 19 (Labor Day Classic) | 20:00:078:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-06 23:59:13March 6, 2021 |   East Tennessee State at Wofford | 23:59:13Postponed | Gibbs Stadium | Spartanburg, SC |
North Dakota 21, South Dakota 10
Albany 24, New Hampshire 20
LIU 24, Bryant 19
Duquesne 30, Sacred Heart 27
UT Martin 28, Eastern Illinois 15
Jacksonville State 38, Tennessee State 16
Murray State 24, Southeast Missouri State 21
Wagner at Merrimack