| 2021-03-06 12:00:13March 6, 2021 |   East Tennessee State at Wofford | 12:00:1312:00 pm | Gibbs Stadium | Spartanburg, SC |
| 2021-03-06 12:00:22March 6, 2021 |   Southern Illinois at Youngstown State | 12:00:2212:00 pm | Stambaugh Stadium | Youngstown, OH |
| 2021-03-06 12:00:49March 6, 2021 |   Maine at Delaware | 12:00:4912:00 pm | Delaware Stadium | Newark, DE |
| 2021-03-06 12:00:55March 6, 2021 |   Villanova at Stony Brook | 12:00:5512:00 pm | LaValle Stadium | Stony Brook, NY |
| 2021-03-06 13:00:06March 6, 2021 |   Jackson State at Grambling State | 13:00:061:00 pm | Eddie Robinson Stadium | Grambling, LA |
| 2021-03-06 13:00:07March 6, 2021 |   Chattanooga at The Citadel | 13:00:071:00 pm | Johnson Hagood Stadium | Charleston, SC |
| 2021-03-06 13:00:08March 6, 2021 |   William and Mary at Richmond | 13:00:081:00 pm | Robins Stadium | Richmond, VA |
| 2021-03-06 13:00:23March 6, 2021 |   Presbyterian at Gardner-Webb | 13:00:231:00 pm | Spangler Stadium | Boiling Springs, NC |
| 2021-03-06 13:00:27March 6, 2021 |   Samford at Furman | 13:00:271:00 pm | Paladin Stadium | Greenville, SC |
| 2021-03-06 13:30:49March 6, 2021 |   James Madison at Elon | 13:30:491:30 pm | Rhodes Stadium | Elon. NC |
| 2021-03-06 14:00:15March 6, 2021 |   Idaho State at Southern Utah | 14:00:152:00 pm | Eccles Coliseum | Cedar City, UT |
| 2021-03-06 15:00:27March 6, 2021 |   UC Davis at Idaho | 15:00:273:00 pm | Kibbie Dome | Moscow, ID |
| 2021-03-06 15:00:29March 6, 2021 |   Western Illinois at South Dakota State | 15:00:293:00 pm | Dykhouse Stadium | Brookings, SD |
| 2021-03-06 15:00:37March 6, 2021 |   North Dakota State at Missouri State | 15:00:373:00 pm | Plaster Stadium | Springfield, MO |
| 2021-03-06 15:00:55March 6, 2021 |   Mississippi College at Tarleton State | 15:00:553:00 pm | Memorial Stadium (Tarleton State) | Stephenville, TX |
| 2021-03-06 16:00:45March 6, 2021 |   Incarnate Word at Lamar | 16:00:454:00 pm | Provost Umphrey Stadium | Beaumont, TX |
| 2021-03-06 16:00:59March 6, 2021 |   Weber State at Cal Poly | 16:00:594:00 pm | Alex G. Spanos Stadium | San Luis Obispo, CA |
| 2021-03-06 17:00:22March 6, 2021 |   Illinois State at Northern Iowa | 17:00:225:00 pm | UNI-Dome | Cedar Falls, IA |
| 2021-03-06 19:00:09March 6, 2021 |   Alabama A&M at Mississippi Valley State | 19:00:097:00 pm | Rice-Totten Stadium | Itta Bena, MS |
| 2021-03-06 19:00:54March 6, 2021 |   McNeese State at Southeastern Louisiana | 19:00:547:00 pm | Strawberry Stadium | Hammond, LA |
| 2021-03-06 19:00:58March 6, 2021 |   Nicholls at Northwestern State | 19:00:587:00 pm | Turpin Stadium | Natchitoches, LA |
| 2021-03-06 20:00:07March 6, 2021 |   Texas Southern at Prairie View A&M | 20:00:078:00 pm | Panther Stadium | Prairie View, TX |
| 2021-03-06 23:59:00March 6, 2021 |   VMI at Western Carolina | 23:59:00TBD | E.J. Whitmire Stadium | Cullowhee, NC |
| 2021-03-06 23:59:13March 6, 2021 |   Northern Arizona at Eastern Washington | 23:59:13TBD | Roos Field | Cheney, WA |
| 2021-03-06 23:59:14March 6, 2021 |   Arkansas-Pine Bluff at Southern | 23:59:14TBD | A.W. Mumford Stadium | Baton Rouge, LA |
| 2021-03-06 23:59:38March 6, 2021 |   South Carolina State at Howard | 23:59:38TBD | Greene Stadium | Washington, DC |
| 2021-03-06 23:59:49March 6, 2021 |   Dixie State at New Mexico State | 23:59:49TBD | Aggie Memorial Stadium | Las Cruces, NM |
South Dakota at North Dakota
Albany at New Hampshire
Bryant at LIU
Sacred Heart at Duquesne
Jacksonville State at Tennessee State
Wagner at Merrimack
Murray State at Southeast Missouri State
Eastern Illinois at UT Martin